Of course, you could easily spend a full two-week vacation just in one of Italy's major destinations and not even come close to seeing it all. (I've spent about four years of my life in Rome and feel like have barely scratched the surface.) And maybe that's just what you have in mind, which is why I've compiled lists of top sights and such to help you craft your own week or two in Rome, Florence, or Venice.
However, if you're trying to cram the best of each city into just a day or three, I can help. Here's how to spend one, two, or three days in each of Italy's major cities.
One of the easiest ways to pack as much sightseeing in as possible to to take guided day tours—perhaps a walking tour of Ancient Rome with an archaeologist, or a guided visit to the Uffizi in Florence, or a gondola tour of Venice:
I will freely admit to being as guilty as anyone of this, but: Please try not to overplan your trip to Italy. That's a two-fold plea:
Lodging: Booking.com, Bedandbreakfast.com, Airbnb.com, Rentalo.com, Vrbo.com, Belvilla.com, Hostelworld.com, Hostelbookers.com, Couchsurfing.com, Homeexchange.com
Packages: SelectItaly.com, Gotoday.com, Orbitz.com, Expedia.com, Travelocity.com
Maps & guides: Amazon.com, Maps.google.com, Tuttocitta.it
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Lodging: Booking.com, Bedandbreakfast.com, Airbnb.com, Rentalo.com, Vrbo.com, Belvilla.com, Hostelworld.com, Hostelbookers.com, Couchsurfing.com, Homeexchange.com
Packages: SelectItaly.com, Gotoday.com, Orbitz.com, Expedia.com, Travelocity.com
Maps & guides: Amazon.com, Maps.google.com, Tuttocitta.it